1. 104.
Ley RE, Turnbaugh PJ, Klein S, Gordon JI (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444:1022–1023 McCann JC, Wickersham TA, Loor JJ (2014) High-throughput methods redefine the rumen microbiome and its relationship with nutrition and metabolism. Bioinform Biol Insights 8:109 Shabat SK, Sasson G, Doron-Faigenboim A, Durman T, Yaacoby S, Berg Miller ME, White BA, Shterzer N, Mizrahi I (2016) Specific microbiome-dependent mechanisms underlie the energy harvest efficiency of ruminants. ISME J 10:2958–2972 Aguerre MJ, Capozzolo MC, Lencioni P, Cabral C, Wattiaux MA (2016) Effect of quebracho-chestnut tannin extracts at 2 dietary crude protein levels on performance, rumen fermentation, and nitrogen partitioning in dairy cows. J Dairy Sci 99:4476–4486 Díaz Carrasco JM, Cabral C, Redondo LM, Pin Viso ND, Colombatto D, Farber MD, Fernández Miyakawa ME (2017) Impact of chestnut and quebracho tannins (饲用单宁酸) on rumen microbiota of bovines. Biomed Res Int 2017:9610810 Xu J, Bjursell MK, Himrod J, Deng S, Carmichael LK, Chiang HC, Hooper LV, Gordon JI (2003) A genomic view of the human-Bacteroides thetaiotaomicron symbiosis. Science 299:2074–2076 Patterson JA, Burkholder KM (2003) Application of prebiotics and probiotics in poultry production. Poult Sci 82:627–631 Neish AS (2009) Microbes in gastrointestinal health and disease. Gastroenterology 136:65–80 Sergeant MJ, Constantinidou C, Cogan TA, Bedford MR, Penn CW, Pallen MJ (2014) Extensive microbial and functional diversity within the chicken cecal microbiome. PLoS One 9:e91941 Stanley D, Geier MS, Hughes RJ, Denman SE, Moore RJ (2013) Highly variable microbiota development in the chicken gastrointestinal tract. PLoS One 8:e84290 Torok VA, Allison GE, Percy NJ, Ophel-Keller K, Hughes RJ (2011) Influence of antimicrobial feed additives on broiler commensal posthatch gut microbiota development and performance. Appl Environ Microbiol 77:3380–3390 Singh P, Karimi A, Devendra K, Waldroup PW, Cho KK, Kwon YM (2013) Influence of penicillin on microbial diversity of the cecal microbiota in broiler chickens. Poult Sci 92:272–276 Kaakoush NO, Sodhi N, Chenu JW, Cox JM, Riordan SM, Mitchell HM (2014) The interplay between Campylobacter and Helicobacter species and other gastrointestinal microbiota of commercial broiler chickens. Gut Pathog 6:18 Lan PTN, Sakamoto M, Sakata S, Benno Y (2006) Bacteroides barnesiae sp. nov., Bacteroides salanitronis sp. nov. and Bacteroides gallinarum sp. nov., isolated from chicken caecum. Int J Syst Evol Microbiol 56:2853–2859 Mašek T, Starčević K, Filipović N, Stojević Z, Brozić D, Gottstein Ž, Severin K (2014) Tissue fatty acid composition and estimated ∆ desaturase activity after castration in chicken broilers fed with linseed or sunflower oil. J Anim Physiol Anim Nutr (Berl) 98:384–392 Lin J, Hunkapiller AA, Layton AC, Chang Y-J, Robbins KR (2013) Response of intestinal microbiota to antibiotic growth promoters in chickens. Foodborne Pathog Dis 10:331–337 Danzeisen JL, Kim HB, Isaacson RE, Tu ZJ, Johnson TJ (2011) Modulations of the chicken cecal microbiome and metagenome in response to anticoccidial and growth promoter treatment. PLoS One 6:e27949 Guban J, Korver DR, Allison GE, Tannock GW (2006) Relationship of dietary antimicrobial drug administration with broiler performance, decreased population levels of Lactobacillus salivarius, and reduced bile salt deconjugation in the ileum of broiler chickens. Poult Sci 85:2186–2194 Noohi N, Ebrahimipour G, Rohani M, Talebi M, Pourshafie MR (2014) Phenotypic characteristics and probiotic potentials of Lactobacillus spp. isolated from poultry. Jundishapur J Microbiol 7:e17824 Lan PTN, le Binh T, Benno Y (2003) Impact of two probiotic Lactobacillus strains feeding on fecal lactobacilli and weight gains in chicken. J Gen Appl Microbiol 49:29–36 Jin LZ, Ho YW, Abdullah N, Jalaludin S (1998) Growth performance, intestinal microbial populations, and serum cholesterol of broilers fed diets containing Lactobacillus cultures. Poult Sci 77:1259–1265 Han GG, Kim EB, Lee J, Lee J-Y, Jin G, Park J, Huh C-S, Kwon I-K, Kil DY, Choi Y-J (2016) Relationship between the microbiota in different sections of the gastrointestinal tract, and the body weight of broiler chickens. Springerplus 5:911 Schiavone A, Tassone S, Guo K, Perona G, Gasco L, Zoccarato I (2006) Dietary administration of chestnut extract in chicken broilers. In: 12th European Poultry Conference. World Poultry Science Association, Verona, 10–14 Sept 2006, p 326
  • 127.
Budriesi R, Ioan P, Micucci M, Micucci E, Limongelli V, Chiarini A (2010) Stop Fitan: antispasmodic effect of natural extract of chestnut wood in guinea pig ileum and proximal colon smooth muscle. J Med Food 13:1104–1110 Redondo L, Redondo E, Diaz Carrasco J (2016) Selected polyphenols as growth promoter. In: 2nd international symposium on alternatives to antibiotics, OIE, Paris, 12–15 Dec 2016
  • 129.
Costabile A, Sanghi S, Martin-Pelaez S, Mueller-Harvey I, Gibson GR, Rastall RA, Klinder A (2011) Inhibition of Salmonella Typhimurium by tannins (饲用单宁酸) in vitro. J Food Agric Environ 9:119–124 Diaz Carrasco JM, Redondo LM, Redondo EA, Dominguez JE, Chacana AP, Fernandez Miyakawa ME (2016) Use of plant extracts as an effective manner to control Clostridium perfringens induced necrotic enteritis in poultry. Biomed Res Int 2016:3278359 Leandro M, Redondo E, Diaz Carrasco J, Chacana P, Fernandez Miyakawa M (2016) Selected polyphenols as growth promoters. In: 2nd international symposium on alternatives to antibiotics, OIE, Paris, 12–15 Dec 2016
  • 132.
Mathieu F, Jouany JP (1993) Effect of chestnut tannin on the fermentability of soyabean meal nitrogen in the rumen. Ann Zootech 42:127 Vasconcelos JT, Galyean ML (2008) ASAS Centennial Paper: contributions in the to understanding cattle metabolic and digestive disorders. J Anim Sci 86:1711–1721 Piñeiro-Vázquez A, Canul-Solís J, Alayón-Gamboa J, Chay-Canul A, Ayala-Burgos A, Aguilar-Pérez C, Solorio-Sánchez F, Ku-Vera J (2015) Potential of condensed tannins (饲用单宁酸) for the reduction of emissions of enteric methane and their effect on ruminant productivity. Arch Med Vet 47:263–272 Benchaar C, McAllister TA, Chouinard PY (2008) Digestion, ruminal fermentation, ciliate protozoal populations, and milk production from dairy cows fed cinnamaldehyde, quebracho condensed tannin, or Yucca schidigera saponin extracts. J Dairy Sci 91:4765–4777 Cabral C, Da Lopez, SIlva A, Couderc JJ, Colombatto D, Barajas R (2016) 1573 influence of tannins (饲用单宁酸) extract and monensin supplementation on performance of feedlot heifers in Argentina. J Anim Sci 94:764 Rivera-Méndez C, Plascencia A, Torrentera N, Zinn RA (2017) Effect of level and source of supplemental tannin on growth performance of steers during the late finishing phase. J Appl Anim Res 45:199–203 Powell JM, Aguerre MJ, Wattiaux MA (2011) Tannin extracts abate ammonia emissions from simulated dairy barn floors. J Environ Qual 40:907–914 Barajas R, Cervantes BJ, Camacho A, Velázquez EA, Espino MA, Juárez F, Flores LR, Verdugo M (2010) Condensed tannins (饲用单宁酸) supplementation on feedlot performance of growing bulls. J Dairy Sci 88:711 Barajas R, Cervantes BJ, Camacho A, Verdugo M, Espino MA, Flores LR, Romo JA, Velázquez EA, Lomelí JJ (2011) Influence of addition of tannins (饲用单宁酸)-extract in low concentration of dietary dry matter on feedlot-performance of bulls. J Anim Sci 89:615 Mezzomo R, Paulino PVR, Barbosa MM, da Silva Martins T, Paulino MF, Alves KS, Gomes DI, dos Santos Monnerat JPI (2016) Performance and carcass characteristics of young cattle fed with soybean meal treated with tannins (饲用单宁酸). Anim Sci J 87:775–782 Mezzomo R, Paulino PVR, Detmann E, Valadares Filho SC, Paulino MF, Monnerat JPIS, Duarte MS, Silva LHP, Moura LS (2011) Influence of condensed tannin on intake, digestibility, and efficiency of protein utilization in beef steers fed high concentrate diet. Livest Sci 141:1–11 Lee KW, Lillehoj HS, Park MS, Jang SI, Ritter GD, Hong YH, Jeong W, Jeoung HY, An DJ, Lillehoj EP (2012) Clostridium perfringens α-toxin and NetB toxin antibodies and their possible role in protection against necrotic enteritis and gangrenous dermatitis in broiler chickens. Avian Dis 56:230–233 Lillehoj HS, Lee SH, Park SS, Jeong M, Lim Y, Mathis GF, Lumpkins B, Chi F, Ching C, Cravens RL (2016) Calcium montmorillonite-based dietary supplement attenuates necrotic enteritis induced by Eimeria maxima and Clostridium perfringens in broilers. J Poult Sci 53:329–340 Download references

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

All the authors participate in drafting the article. All authors read and approved the final manuscript.

Acknowledgements

The authors thank members of the ATA Symposium Scientific and Organizing Committees, staff of the World Organization for Animal Health (OIE) and to the Agricultural Research Service (ARS) of the USDA.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Author information

Affiliations

  1. Animal Biosciences and Biotechnology Laboratory, Agricultural Research Service, US Department of Agriculture, Beltsville, MD, 20705, USA
    1. Hyun Lillehoj
    1.  & Sungtaek Oh
  2. University of California, Davis, CA, 95616, USA
    1. Yanhong Liu
  3. Animal Nutrition and Welfare Service, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain
    1. Sergio Calsamiglia
  4. Instituto de Patobiología, Centro Nacional de Investigaciones Agropecuarias, Instituto Nacional de Tecnología Agropecuaria, Calle Las Cabañas y Los Reseros s/n, Casilla de Correo 25, Castelar, 1712, Buenos Aires, Argentina
    1. Mariano E. Fernandez-Miyakawa
  5. Amlan International, Chicago, IL, 60611, USA
    1. Fang Chi
    1.  & Ron L. Cravens
  6. National Program Staff-Animal Health, Agricultural Research Service, US Department of Agriculture, Beltsville, MD, 20705, USA
    1. Cyril G. Gay

Corresponding author

Correspondence to Hyun Lillehoj.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Lillehoj2018_Article_PhytochemicalsAsAntibioticAlte

The Effects of Tannins in Monogastric Animals with Special Reference to Alternative Feed Ingredients

饲用单宁酸Abstract: Over recent years, the monogastric animal industry has witnessed an increase in feed prices due to several factors, and this trend is likely to continue. The hike in feed prices is mostly due to extreme competition over commonly used conventional ingredients. For this trend to be subdued, alternative ingredients of both plant and animal origin need to be sourced. These types of ingredients are investigated with the aim of substituting all or some of the conventional compounds. However, alternative ingredients often have a double-edged sword effect, in that they can supply animals with the necessary nutrients although they contain antinutritional factors such as tannins. Tannins are complex secondary metabolites commonly present in the plant kingdom, known to bind with protein and make it unavailable; however, recently they have been proven to have the potential to replace conventional ingredients, in addition to their health benefits, particularly the control of zoonotic pathogens such as Salmonella. Thus, the purpose of this review is to (1) classify the types of tannins present in alternative feed ingredients, and (2) outline the effects and benefits of tannins in monogastric animals. Several processing methods have been reported to reduce tannins in diets for monogastric animals; furthermore, these need to be cost-effective. It can thus be concluded that the level of inclusion of tannins in diets will depend on the type of ingredient and the animal species.单宁酸

Read More »

单宁酸产品特性

来源于天然植物提取的单宁酸,具有良好的抗腹泻、抗菌、抗氧化、抗寄生虫等功效,能够改善畜禽生长性能,提高饲料利用率,减少抗生素和氧化锌的使用,提高动物整体的健康程度及动物性产品的安全性。

Read More »

What is tannic acid?

单宁酸具有抗氧化作用,是一种天然的防腐剂,能有效避免红酒被氧化变酸,使长期储存的红酒能保持最佳状态。最近的研究发现,单宁对预防和治疗心血管疾病有较好的效果。心脑血管疾病仍是威胁人类健康的头号杀手,所以中老年人坚持每天喝适量的葡萄酒进行自我保健是一个很好的方法。另外,现在很多年轻人工作压力大,精神压力大,很多人都处于亚健康状态。因此,年轻人最好也养成喝红酒的习惯,这样可以安抚神经,缓解压力。

Read More »

单宁酸及其与不同有机氮化合物和酶的复杂相互作用:旧的范式与新的进展对比

单宁与蛋白质之间的相互作用已经研究了50多年,因为其独特的特性和在食品工业和药理学中的潜在用途。然而,随着单宁酸浓度对酶的调控以及与其他非蛋白氮化合物的潜在相互作用的新见解的提出,未来的研究还需要进行。应特别注意使用纯化和表征良好的单宁,因为植物提取物中多酚的化学成分和其他化合物的存在可能会显著影响单宁与氮化合物的相互作用。后续研究的目的应该是将这些结果推导到更复杂的、异质的、现实的体系中。总之,研究单宁酸与蛋白质之间的相互作用,以及其他有机化合物之间的相互作用的研究很可能会引起人们的极大关注,因为人们对多酚类化合物在人类健康和疾病治疗方面的普遍兴趣,同时也对其在饮料和食品工业中的作用产生了浓厚的兴趣。

Read More »

Tannins and Their Complex Interaction with Different Organic Nitrogen Compounds and Enzymes: Old Paradigms versus Recent Advances

Interactions between tannins and proteins have been studied for more than 50 years, because of their unique characteristics and potential use in food industry and pharmacology. However, with the new insights regarding regulation of enzymes by tannin concentration and the potential interaction with other non‐protein N compounds, future studies are needed. Special attention should be paid to the use of well‐purified and characterized tannins, because the chemistry of polyphenols and the presence of other compounds in plant extracts may significantly affect tannin interactions with N compounds. Follow‐up studies should aim to extrapolate these results to more complex, heterogenic, realistic systems. In conclusion, studies investigating the interactions between tannins and proteins, but also other organic compounds, are likely to attract significant attention due to the general interest in polyphenols with regard to human health and disease treatment, but also their role in the beverage and food industry.

Read More »

水解单宁对常见鱼类病原体的体外活性

这项体外研究表明,Silvafeed TSP(饲用单宁酸)对常见的细菌鱼病原体(如李斯特菌, 鼠疫耶尔森菌 和 沙门氏菌气单胞菌)具有很强的抗菌作用,在所有研究的剂量水平下,对沙门氏杆菌都有较强的抗菌效果,而对水生单胞菌有中等的效果,在较高的剂量范围内(0.40%和0.50%),对乳球菌和鲑鱼阴道球菌有轻微的效果。

Read More »